Projects :Clinical Infection Research Group

Fluent

A Phase 3, Randomized, Observer-blind, Active-controlled Study to Investigate the Safety, Reactogenicity, and Efficacy of mRNA-1010 Candidate Seasonal Influenza Vaccine Compared with a Licensed Inactivated Seasonal Influenza Vaccine in Adults ≥50 Years of Age

<img src="https://www.cirg-edinburgh.co.uk/wp-content/themes/cirg/img/placeholder-img.png">

SNAP

Staphylococcus aureus Network Adaptive Platform trial

B-WELL 1

Phase 3 Multicenter, Randomized, Double-Blind, Study to Assess the Efficacy and Safety of Treatment with Bepirovirsen in HBeAg_negative Nucleos(t)ide Analogue-treated Participants with Chronic Hepatitis B Virus

UKAR

UK Antimicrobial Registry

Define AP3

Define Appendix 3 (VST Therapy)

<img src="https://www.cirg-edinburgh.co.uk/wp-content/themes/cirg/img/placeholder-img.png">

MIDAS

Measuring the impact of Improved Diagnostics on Antimicrobial Stewardship in Respiratory Tract Infection

Odyssey

Phase 1/2, randomized, observer-blind, dose-ranging study to evaluate the safety, reactogenicity, and immunogenicity of mRNA-1018 pandemic influenza candidate vaccines in healthy adults ≥18 years of age

MISTRAL

Microbiome-based stratification of individuals at risk of HIV-1 acquisition, chronic clinical complications, antimicrobial drug resistance, and unresponsiveness to therapeutic HIV-1 vaccination

CASCADE

An investigation into the medical and lived experiences of people with recently acquired HIV in Europe and Canada

SUPERNOVA

Study Understanding Pre-Exposure pRophylaxis of NOVel Antibodies (SUPERNOVA)

NEXTCOVE

A randomised, observer-blind, active-controlled Phase 3 study to investigate the safety, immunogenicity, and relative vaccine efficacy of mRNA-1283.222 administered as a booster dose compared with mRNA-1273.222 in participants aged 12 years and older for the prevention of COVID-19

RECOVERY

Randomised Evaluation of COVID-19 Therapy

PANORAMIC

Platform Adaptive trial of NOvel antiviRals for eArly treatMent of covid-19 In the Community

RIO

A randomised placebo controlled trial of ART plus dual long-acting HIV-specific broadly neutralising antibodies (bNAbs) vs ART plus placebo in treated Primary HIV Infection on viral control off ART

EuroSIDA

The EuroSIDA network 2005-2009. Clinical and virological outcome of patients with HIV in Europe

DexEnceph

Dexamethasone in Herpes Simplex Virus Encephalitis Randomised Controlled Trial and Non-HSV Cohort Study

VIBRANT

Vaccine Immunity Breakthrough & Re-Infection – ANtibody & T-cells

PrEPaRe

Pre-exposure Prophylaxis Use in People Newly Diagnosed with HIV

IONOE

Improving Outcomes of Necrotising Otitis Externa

TIDE

A multi-centre, randomised controlled, non-inferiority and cost effectiveness trial comparing Polyhexanide and Chlorhexidine with Neomycin to Mupirocin for nasal methicillin-resistant Staphylococcus aureus (MRSA) decolonisation amongst adult hospital in-patients

HEAL-COVID

HElping Alleviate the Longer-term consequences of COVID-19 (HEAL-COVID)

ISARIC 4C

ISARIC/WHO Clinical Characterisation Protocol for Severe Emerging Infections in the UK (CCP-UK) (Scotland)

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